Hubungan Kadar C-Reactive Protein (CRP) dan Kadar Albumin serta C-Reactive Protein-Albumin Ratio (CAR) dengan Derajat Keparahan Penyakit Parkinson Berdasarkan Hoehn and Yahr Scale

Abstract

Background: Inflammatory processes have a central role in Parkinson's disease. In Parkinson's, there is progressive dopaminergic nerve degeneration in the substantia nigra α-synuclein aggregated increases microglial activation and stimulates the secretion of inflammatory molecules thereby triggering neuroinflammation that triggers oxidative stress and exacerbates dopaminergic neurodegeneration. C-reactive Protein (CRP) and albumin can be used as markers of systemic inflammation and oxidative stress in Parkinson's disease. Increased CRP, decreased albumin levels, and increased C-reactive proteinalbumin Ratio (CAR) are associated with increased severity of Parkinson's disease. Objective: To find out the relationship between rates of C-Reactive Protein (CRP), albumin levels, and C-Reactive Protein-Albumin Ratio (CAR) with the severity of Parkinson's disease based on the Hoehn and Yahr Scale. Method: This research uses a cross-sectional design. Research subjects were Parkinson's disease sufferers at the Neurology Polyclinic at Adam Malik Hospital, Medan, and Network Hospital from November 2023 to July 2024 who met the inclusion criteria. Assessment of the severity of the disease using Hoehn and Yahr Scale. Measurements of CRP, albumin, and CAR levels were obtained from patient blood samples. Data analysis using tests Mann Whitney. Results: Of the 37 research subjects, the average age was 62.54 ± 8.74 years, the majority were men (62.2%), the majority had a bachelor's degree (32.4%), civil servant work (35.1%), Batak ethnicity (67, 6%), nutritional status norm weight (89.2%), and the majority of Parkinson's disease severity was mild to moderate (70.3%). Median CRP levels were 0.8 mg/L, albumin 4.3 g/dL, and CAR 0.18. Based on test Mann Whitney There were significant differences in CRP, albumin, and CAR levels between patients with severe Parkinson's disease and mildmoderate Parkinson's disease with values of p<0.001, p=0.004, and p<0.001. Conclusion: There are significant differences in CRP, albumin, and CAR levels between patients with severe Parkinson's disease and mild-moderate Parkinson's disease.