Hubungan Asupan Zat Besi dan Kadar Serum Feritin dengan Migren

Abstract

Background: Migraine is a chronic neurovascular disease characterized by recurrent headache attacks with moderate to severe intensity. Iron is an important element that regulates brain function, cell function, energy metabolism, and neurotransmitter synthesis. Several studies have linked the relationship between iron intake and serum ferritin levels with migraine, but until now it is still not clearly understood. Objective: To determine the relationship between iron intake and serum ferritin levels with attack frequency, headache intensity, headache duration and disability in migraine sufferers. Method: This study is an observational analytical study with a cross-sectional design. This study was conducted at Prof. Chairuddin P. Lubis USU Hospital and satellite hospitals. The data used in this study are primary data, namely filling out research questionnaires, medical interviews, 2x24 food recall interviews and serum ferritin laboratory test results. Results: There were 46 subjects who met the inclusion criteria who were included in this study. A significant weak negative correlation was found between iron intake and attack frequency (r=-0.358, p=0.014), headache intensity (r=-0.347, p=0.018), and disability in migraine sufferers (r=-0.302, p=0.041). In addition, a significant weak negative correlation was found between serum ferritin levels and attack frequency (r=-0.298, p=0.044), headache intensity (r=-0.319, p=0.031) and disability in migraine sufferers (r=-0.318, p=0.031). No correlation was found between iron intake and headache duration (p=0.632, r=-0.073). There was no correlation between serum ferritin levels and headache duration (p=0.127; r=- 0.228). Conclusion: There is a weak and significant negative correlation between iron intake and serum ferritin levels with attack frequency, headache intensity, and disability in migraine sufferers. There was no correlation between iron intake and serum ferritin levels with migraine headache duration.