| dc.description.abstract | Background: Migraine is a chronic neurovascular disease characterized by
recurrent headache attacks with moderate to severe intensity. Iron is an important
element that regulates brain function, cell function, energy metabolism, and
neurotransmitter synthesis. Several studies have linked the relationship between
iron intake and serum ferritin levels with migraine, but until now it is still not
clearly understood.
Objective: To determine the relationship between iron intake and serum ferritin
levels with attack frequency, headache intensity, headache duration and disability
in migraine sufferers.
Method: This study is an observational analytical study with a cross-sectional
design. This study was conducted at Prof. Chairuddin P. Lubis USU Hospital and
satellite hospitals. The data used in this study are primary data, namely filling out
research questionnaires, medical interviews, 2x24 food recall interviews and serum
ferritin laboratory test results.
Results: There were 46 subjects who met the inclusion criteria who were included
in this study. A significant weak negative correlation was found between iron intake
and attack frequency (r=-0.358, p=0.014), headache intensity (r=-0.347,
p=0.018), and disability in migraine sufferers (r=-0.302, p=0.041). In addition, a
significant weak negative correlation was found between serum ferritin levels and
attack frequency (r=-0.298, p=0.044), headache intensity (r=-0.319, p=0.031) and
disability in migraine sufferers (r=-0.318, p=0.031). No correlation was found
between iron intake and headache duration (p=0.632, r=-0.073). There was no
correlation between serum ferritin levels and headache duration (p=0.127; r=-
0.228).
Conclusion: There is a weak and significant negative correlation between iron
intake and serum ferritin levels with attack frequency, headache intensity, and
disability in migraine sufferers. There was no correlation between iron intake and
serum ferritin levels with migraine headache duration. | en_US |
