Korelasi Peningkatan Serum Alfa Fetoprotein dengan Ukuran dan Jumlah Tumor Berdasarkan CT-Scan Liver Tiga Fase pada Karsinoma Sel Hati di RSUP Haji Adam Malik Medan

Abstract

Background: The incidence of hepatocellular carcinoma (HCC) in Indonesia is among the top four most common cancers with an incidence of 18,468 cases in 2018 with 18,148 cases who died. Fetoprotein alpha (AFP) is the first oncofetal biomarker to be identified in patients with KSH and undifferentiated teratoma. AFP is known to regulate normal and neoplastic cells through several mechanisms including apoptotic regulation and modulation of cytoplasmic signaling. Objective: To analyze the correlation between serum alpha fetoprotein and tumor size and number in liver cell carcinoma cases at H. Adam Malik General Hospital Medan. Methods: Analytical research using a case series design where all research subjects were patients with hepatocellular carcinoma based on a three-phase CT scan then measured the tumor and its number. Data analysis using Spearman correlation test. Results: Total 80 samples showed that most patients were male (85%) and the age range was above 60 years (33.8%). There was a significant correlation between serum AFP with tumor size (p=0.042) and tumor number (p=0.019) in hepatocellular carcinoma patients with weak correlation degree. Conclusion: There is a correlation between elevated serum alpha fetoprotein and tumor size and number based on three-phase liver ct-scan in hepatocellular carcinoma at Hajj adam malik general hospital so that early detection of tumor recurrence or metastasis through AFP monitoring and imaging surveillance can enable timely intervention and improve patient outcomes.