Hubungan Kadar Brain-Derived Neurotrophic Factor (BDNF) Serum dengan Komplikasi Neurologis pada Pasien Tumor Intrakranial

Abstract

Background: Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophic substance that plays an important role in maintaining neuronal survival, differentiation, and synaptic plasticity. Evidence suggests that BDNF deficits are interconnected with many neurological diseases including intracranial tumors. In the study, BDNF levels were found to influence the incidence of delirium and seizures in patients with intracranial tumors. Objective: To determine the relationship between serum Brain-Derived Neurotrophic Factor (BDNF) levels with neurological complications in intracranial tumor patients at Adam Malik Hospital, Medan Method: This study used a cross sectional design. Research subjects were sufferers of intracranial tumors at Adam Malik Hospital in Medan during August - October 2024 who met the inclusion criteria. Measurement of BDNF levels is obtained from patient blood samples. Delirium was assessed using the Confusion Assessment Method (CAM) questionnaire and seizures were observed during treatment. Data analysis used One Way Anova and Post Hoc Games-Howell tests. Results: Of the 50 research subjects, the majority were women (58%), Average age was 50.56 years. The highest education level was high school (44%), the most common occupation was a housewife (38%) and the most common type of intracranial tumor was primary brain tumor (54%). The most common complication was delirium (32%). Based on the One Way Anova test, there is a relationship between Brain-Derived Neurotrophic Factor (BDNF) levels and neurological complications in patients with intracranial tumors (p<0.001). Based on the Post Hoc Games-Howell test, there was a significant difference between groups (p<0.001) but in the seizure group and the group without delirium and seizures there was no significant difference (p>0.05). Conclusion: There is a relationship between Brain-Derived Neurotrophic Factor (BDNF) levels and neurological complications in the form of delirium in patients with intracranial tumors.