Analisis Hubungan Kadar C-Reactive Protein dan Kualitas Hidup Terhadap Sindrom Depresif pada Pasien Rheumatoid Arthritis

Abstract

Background: Rheumatoid Arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation that can damage joints and extra-articular organs caused by the interaction of genetic and environmental factors involving the synovial joints. Quality of life in RA is mainly influenced by the patient's physical symptoms, such as fatigue, pain, stiffness, and impaired physical function. In addition, given the progressive nature of the disease and the unpredictable course of RA, the disease may have adverse psychological effects, such as depression. RA patients are more susceptible to anxiety, depression, and cognitive impairment compared to the general healthy population. Depression is twice as common in RA compared to the general population and is the most common mental health disorder associated with RA. There is a significant correlation between CRP levels and tissue inflammation scores from knee synovial biopsy samples in RA patients.

Methods: Samples were taken using a non-probability sampling method of consecutive sampling type, with a sample size of 75 RA patients. The analysis tests used in this study were Chi Square and Spearman.

Results: The female subjects were the most, which were 74 people (98.6%), The median age was 54 years. The subjects who did not work and had a high school education were the most with 47 (62.7%) and 50 (66.7%) respectively. CRP levels and depressive syndrome had a positive correlation with an r value of 0.499. Quality of life and depressive syndrome were negatively correlated with an r value of -0.746.

Conclusion: This study found a relationship between CRP levels and quality of life on depressive syndrome in RA patients.