Hubungan Kadar Neutrofil Limfosit Rasio (NLR), Platelet Limfosit Rasio (PLR) dan Monosit Limfosit Rasio (MLR) dengan Mortalitas pada Pasien Sepsis di ICU RSUP Haji Adam Malik Medan

Abstract

Objective: To determine the relationship between the levels of Neutrophil Lymphocyte Ratio (NLR), Monocyte Lymphocyte Ratio (MLR), and Platelet Lymphocyte Ratio (PLR) upon ICU admission and the mortality rate of sepsis patients at RSUP Haji Adam Malik Medan. Method: This study is an analytic research with a retrospective design, observing the results of Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), and Monocyte Lymphocyte Ratio (MLR) from the time of ICU admission to ICU discharge, with the aim of assessing the mortality rate of sepsis patients. The data used was obtained from medical records, involving 48 patients diagnosed with sepsis from January 2023 to December 2023. The study applied significance tests to compare the characteristics of two groups before and after treatment using the Wilcoxon test, while clinical parameters between the two groups were compared using the Mann-Whitney test. Results: In the deceased group, there were more female patients, with 19 patients (52.8%) compared to 17 male patients (47.2%). In the survival group, there were more male patients, with 7 patients (58.3%) compared to 5 female patients (41.7%). In the deceased group, the average NLR at the beginning of the study was 18.97 ± 16.28, and there was no significant increase by the end of the study, with the average NLR value rising to 20.78 ± 17.20 (p = 0.300). In the survival group, the average NLR at the beginning was 16.5 ± 18.17, and there was no significant increase by the end of the study, with the average NLR value rising to 17.96 ± 14.08 (p = 0.480). In the deceased group, the average PLR at the beginning of the study was 306.29 ± 239.07, and there was no significant increase by the end of the study, with the average PLR value rising to 5404.39 ± 21293.03 (p = 0.741). At the start of the study, the average MLR value in the deceased group was higher compared to the survival group, but statistical testing showed no significant difference in the average initial MLR values between the two groups (p = 0.299). Conclusion: There were no significant differences between gender and age in both groups (p-value > 0.05). Among the 48 patients studied, no significant relationship was found between the variables examined NLR, PLR, and MLR and mortality in sepsis patients.