Pengaruh Ekstrak Etanol Daun Kelor (Moringa oleifera L.) pada Histologi Hati Tikus (Rattus norvegicus L.) Model Kanker Payudara

Abstract

Breast cancer damages organs and tissues in the body, including the liver. The leaves of moringa (Moringa oleifera L.) contain metabolite compounds, such as flavonoids, alkaloids, tannins, saponins and terpenoids/steroids, which act as antioxidants and as a trigger improvement in the histological structure of the liver. This study aims to determine the effect of ethanol extract of Moringa leaves on the liver morphology and histology of rats (Rattus norvegicus L.), a model of breast cancer induced by 7,12-Dimethylbenz[a]Anthracene (DMBA). The research used experimental methods and a completely randomized design (CRD) by six treatments and four replicates. The treatments consisted of K0, mice without treatment; the negative control, induced only by DMBA at a concentration of 50 mg/kg bw. Positive controls done by given the chemotherapy drug doxorubicin at a concentration of 15 mg/kg bw. Next, groups P1, P2 and P3 were given by moringa leaf ethanol extract with concentrations of 100, 200, 300 mg/kg bw. The results of the study show that the administration of moringa leaf ethanol extract by a concentration of 200 mg/kg bw is able to improve the liver morphology in terms of liver surface colour, reducing liver weight and volume and to reduce the level of hepatocyte cell damage including parenchymatous degeneration, hydropic degeneration and necrosis (p<0.05) as a action of 7,12-Dimethylbenz[a]Anthracene (DMBA).