Pengaruh Kadar Indoksil Sulfat terhadap Kemampuan Fungsional Pasien Penyakit Ginjal Tahap Akhir yang Menjalani Hemodialisa Regular dengan Menggunakan Alat Ukur Skala Karnofsky di Rumah Sakit Umum Pusat Haji Adam Malik Medan

Abstract

Introduction. PGTA is a burdensome disease with high prevalence, mortality, and treatment costs. Indoxyl sulphate is one of the most studied solutes that accumulates in plasma when the kidneys fail. Clinical studies have shown that indoxyl sulphate can predict the prognosis of CKD and CVD in CKD patients. Serum levels of IS are associated with all cause mortality and cardiovascular mortality in CKD patients. The general objective of this study was to determine the relationship of indoxyl sulfate levels to the functional ability of CKD patients undergoing regular haemodialysis using the Karnofsky scale measuring instrument at the Haji Adam Malik Central General Hospital Medan. Methods. This type of research is an observational analytic study with a cross sectional design where data collection is taken to record indoxyl sulfate levels in kidney failure patients undergoing haemodialysis at Adam Malik Hospital. Results. Of all 56 study samples, the mean of the study sample was 49.35 years with a standard deviation of 12.3 years where most patients were dominated by male gender, Batak tribe with PGTA. The mean indoxyl sulphate was 47.32 ug/mL with a standard deviation of 29.19 ug/mL. Basically, most patients came with functional ability calculated by Karnofsky score having category A. The results of analysis with Spearman test showed that there was a moderate negative correlation between indoxyl sulphate levels and functional ability of patients. Conclusion. Indoxyl sulphate levels can be used as an objective parameter to predict a patient's functional ability.