Korelasi Interferon-Gamma terhadap Derajat Aktifitas Penyakit (Sledai-2k) Pasien Systemic Lupus Erythematosus

Abstract

Background: SLE is a chronic autoimmune disease that results in organ damage with variable clinical presentations. The high morbidity and mortality of patients is related to the increasing degree of disease activity. Interferon signalling pathway (IFN-inducile genes) is activated in SLE cases, but its role in increasing the degree of SLE disease activity remains unclear. The purpose of this study was to determine the correlation of IFN gamma to the increase in the degree of activity. Methods: This study used a cross-sectional design conducted for 6 months at H. Adam Malik Hospital Medan by fulfilling the inclusion and exclusion criteria. Data collected included patient's clinical manifestations, SLEDAI score, IFNgamma level examination. The role of IFN gamma on the degree of disease activity was analysed with a correlation test to determine the linearity and strength of the correlation, statistically significant if the p value was <0.05. Results: The study subjects obtained were 67 patients, the majority were female with a ratio of 9:1 and the mean age of the subjects was 35 years, the highest degree of disease activity was moderate 41.8%, the median SDI organ damage score was 1, and the median IFN-gamma level was 31.16 pg/mL. The mean interferon gamma level increased with the degree of disease activity, namely remission (39.48 ± 28.65), mild (93.49 ± 105.5), moderate (200.55 ± 374), and severe (208.84 ± 336), but there was no statistically significant correlation between IFN-gamma and the degree of disease activity (SLEDAI) (r + 0.055; p 0.659). Conclusion: Interferon-gamma levels do not correlate with disease severity.