| dc.description.abstract | Background: Chronic Obstructive Pulmonary Disease (COPD) is a multi-
component disease characterized by mucus hypersecretion, airway narrowing, and
alveolar damage. The prevalence of COPD in Southeast Asian countries is
estimated at 6.3%, with the highest prevalence in Vietnam. Mortality rates for
COPD in men are 11.8% and 8.5% in women. In 2016, COPD ranked fourth in
causes of death, with a mortality rate of 18.6 per 100,000 people. The detection of
increased eosinophil concentration and related pro-inflammatory factors in the
airways and blood of COPD patients highlights the active role of eosinophils in
the inflammatory process in COPD.
Objective: This study aimed to determine the difference in eosinophil levels
between COPD Group B and Group E patients.
Methods: This study employed an observational analytic design using a case-
control approach. The analysis focused on the difference in eosinophil levels
between COPD Group B and Group E patients. A total of 31 patients participated
in the study.
Results: A total of 110 patients were included in the study, with most patients
aged 59–61 years (31.11%) and predominantly male (90%). Patients exhibited
mild to moderate dyspnea (19.4%) and had a history of heavy smoking (80%).
Most patients (29%) had experienced one previous exacerbation episode, and the
majority had a middle school or high school education level, reflecting the socio-
economic status of COPD patients (37%).
Conclusion: This study found no significant difference in eosinophil levels
between COPD Group B and Group E patients. The null hypothesis (H₀), stating
no difference in eosinophil levels between the two groups, was accepted, while
the alternative hypothesis (Hₐ), suggesting a difference, was rejected.
Keywords: Age, Eosinophil, Concentration, COPD | en_US |
