Hubungan Kadar Vitamin D dan Estradiol dengan Overactive Bladder Symptom Score (OABSS) pada Wanita Menopause

Abstract

Introduction. Menopause is a natural phase in a woman's life characterized by the cessation of menstruation and a decrease in estrogen production, which can affect various aspects of health. One common disorder that arises in postmenopausal women is Overactive Bladder Syndrome (OAB), which can reduce quality of life. Estradiol and vitamin D levels are known to play an important role in various bodily functions, including urinary system health. This study aims to explore the relationship between estradiol and vitamin D levels and OAB symptoms in postmenopausal women. Methods. This study used an observational design with a cross-sectional approach. The study subjects were postmenopausal women aged 45-60 years who visited the obstetrics and gynecology clinic. Data collected included age, duration of menopause, estradiol levels, vitamin D levels, and the Overactive Bladder Symptom Score (OABSS). Results. The average age of the postmenopausal women in this study was 56.1 ± 4.68 years, with an average menopause duration of 5.37 ± 1.71 years. The average estradiol level in postmenopausal women was 39.87 ± 7.1 ng/mL, while the average vitamin D level was 19.5 ± 5.59 ng/mL. The average OABSS score in postmenopausal women in this study was 7.96 ± 0.79. The analysis showed a significant relationship between estradiol and vitamin D levels, where lower estradiol levels were associated with lower vitamin D levels in postmenopausal women. Additionally, a significant relationship was found between vitamin D levels and the OABSS score, indicating that higher vitamin D levels were associated with milder OABSS symptoms in postmenopausal women (hypothesis accepted). Similarly, estradiol levels also had a significant relationship with the OABSS score, with higher estradiol levels correlating with milder OABSS symptoms in postmenopausal women (hypothesis accepted). Conclusion. Lower estradiol and vitamin D levels are associated with more severe OABSS symptoms in postmenopausal women. Increasing estradiol and vitamin D levels may potentially alleviate OAB symptoms. Keywords: Postmenopausal women, Estradiol, Vitamin D, OAB, OABSS