| dc.description.abstract | Introduction: According to the 2023 Indonesian health profile, sepsis is the fourth
leading cause of death among neonates, infants, and toddlers. Late-onset neonatal
sepsis refers to sepsis occurring in neonates older than seven days, typically
resulting from nosocomial infection. The difficulty in diagnosing late-onset sepsis
due to atypical symptoms makes it necessary to diagnose based on risk factors of
gestational age and duration of NICU care. Objectives: identify the characteristics
of infants with confirmed late-onset sepsis and to examine the association between
gestational age, duration of NICU care, and the incidence of late-onset neonatal
sepsis. Methods: A cross-sectional study was conducted using medical records
from the perinatology ward of Haji Adam Malik General Hospital, Medan, between
January 2022 and June 2025. Total sampling was employed, including neonates
older than seven days with sepsis confirmed by positive blood cultures. Univariate
and bivariate analyses were performed using SPSS by applying the chi-square test.
Results: Chi-square test showed no relationship between gestational age and the
incidence of late-onset sepsis (p=0.682) but there was a relationship between the
duration of NICU care and the incidence of late-onset sepsis (p=0.014) Conclusion:
From a total of 63 neonates suspected of late-onset sepsis, there were 40 (63.5%)
neonates proven to have late-onset sepsis through positive blood culture. No
relationship found between gestational age and the incidence of late-onset sepsis,
but there was a relationship between the duration of NICU care and the incidence
of late-onset sepsis. Infants with late-onset sepsis were predominantly male, term
gestational age, normal birth weight, maternal risk factors for premature rupture of
membranes, birth in the hospital by c-section, duration of NICU care ≥14 days,
using nasal cannula, CVC, and most of the babies survived. | en_US |
