Response Rate Post Kemoradioterapi pada Penderita KNF di RSUP.H.Adam Malik Medan Tahun 2014 - 2016

Abstract

Latar Belakang : Karsinoma nasofaring (KNF) merupakan tumor ganas yang berasal dari epitel nasofaring.vKNF bersifat radiosensitif dan dapat disembuhkan pada stadium awal. Karena kendala letak anatomis dan sifat tumor yang radiosensitif tinggi, pada stadium lanjut diberikan pengobatan kombinasi kemoradioterapi. Hasil kemoterapi dapat dilihat dari 2 aspek yaitu respon atau hilangnya kanker dan angka ketahanan hidup penderita. Tujuan : Mengetahui hubungan bagaimana response rate post kemoradioterapi pada penderita karsinoma nasofaring di RSUP Haji Adam Malik Medan Tahun 2014 – 2016 Metode : penelitian Analitik dengan desain penelitian cross sectional. Subjek penelitian sebanyak 109 orang pasien KNF yang telah memenuhi kriteria inklusi, untuk menilai Response rate pasien KNF yang telah menjalani pengobatan kemoradioterapi. Hasil : Response rate penderita karsinoma nasofaring di RSUP H. Adam Malik post kemoradioterapi paling banyak memiliki respon parsial yaitu sebanyak 69 penderita (63,3%), dan yang paling sedikit memiliki respon progresif yaitu 5 penderita (4,6 %). Dijumpai hubungan bermakna antara Response rate penderita karsinoma nasofaring tipe undifferentiated terhadap stadium tumor ( P=0,004, P<0,05 ).

Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor derived from epithelial nasofaring. NPC is radiosensitive and curable in its early stages. Due to the anatomical location constraints and the nature of high radiosensitive tumors, advanced stage tumor given the combination treatment of chemoradiotherapy. It results can be viewed from two aspects of response or loss and survival of cancer patients. Aim: To examine the relation about response rate of postchemoradiotherapy patients with nasopharyngeal carcinoma in RSUP H. Adam Malik Hospital Years 2014 – 2016. Methods: Analytic study with cross sectional design. Subjects of the study were 109 NPC patients who had met the inclusion criteria, to assess the response rate of NPC patients who had undergone chemoradiotherapy treatment. Results: Most of post chemoradiotherapy nasopharyngeal carcinoma patients at RSUP H. Adam Malik that had partial response rate were 69 patients (63,3%), and the least progressive response rate were 5 patients (4,6%). A significant relationship was found between the response rate of undifferentiated type nasopharyngeal carcinoma patients to tumor stage (P = 0.004, P <0.05).