Hubungan Kadar 25 (OH) Vitamin D dengan Peningkatan Kadar Procalcitonin pada Pasien Sepsis di RSUP H.Adam Malik Medan

Abstract

Introduction: Sepsis is a complex syndrome caused by an uncontrolled systemic inflammatory response, caused infection. One factor that plays a role in the prognosis of sepsis is vitamin D. Procalcitonin (PCT), a precursor hormone derived from pre-procalcitonin, a biomarker response to infection, and PCT levels can be increased in septic patients. The purpose of this study was to determine the association of 25 (OH) Vitamin D levels with increased PCT levels in septic patients. Methods: This study was conducted with cross sectional design, from August to December 2016. The subjects of this study were septic patients who admitted to the intensive care unit at H. Adam Malik General Hospital Medan, aged >18 years. 25 (OH) vitamin D total and Procalcitonin (PCT) were measured by means of MINI VIDAS BRAHMS, correlation of 25 (OH) Vitamin D and PCT levels was tested using Spearman correlation test, statistical tests with p values <0.05 were considered significant. Results and Discussions: A sample of 33 people consisted of 20 (60.6%) men and 13 (39.4%) women, with an average (SD) age of 53.6 (11.7) years. There were 27 (81.8%) patients reporting hypovitaminosis Vitamin D. That was found a significant negative correlation of total 25 (OH) vitamin D levels with procalcitonin levels (r = - 0.434, p = 0.012). Conclusions: In this study concluded that 81.8% of patients who treated in the ICU had hypovitaminosis Vitamin D. There was a negative correlation between 25 (OH) vitamin D levels and increased procalcitonin levels of septic patients who admitted to the ICU.

Pendahuluan: Sepsis adalah sindrom kompleks yang disebabkan oleh respon inflamasi sistemik yang tidak terkontrol, disebabkan infeksi. Satu faktor yang berperan dalam prognosis sepsis adalah vitamin D. Procalcitonin (PCT), hormon prekursor yang berasal dari pre-procalcitonin, merupakan respon biomarker pada infeksi, dan kadar PCT juga dapat meningkat pada pasien sepsis. Tujuan penelitian ini mengetahui hubungan kadar 25(OH) Vitamin D dengan peningkatan kadar PCT pada pasien sepsis. Metode : Penelitian ini dilakukan dengan metode cross sectional, dari bulan Agustus sampai Desember 2016. Subjek penelitian ini adalah pasien sepsis yang dirawat di ruang rawat intensif RSUP H. Adam Malik Medan.. Kadar 25 (OH) vitamin D total dan Procalcitonin (PCT) di ukur dengan alat MINI VIDAS BRAHMS dan korelasi kadar 25 (OH) Vitamin D dan PCT digunakan uji korelasi Spearman, uji statistik dengan nilai p < 0,05 dianggap bermakna. Hasil dan Pembahasan : Sampel 33 orang terdiri dari 20 (60.6%) laki-laki dan 13 (39.4%) perempuan, dengan rerata (SD) umur 53.6 (11.7) tahun. Yang mengalami hipovitaminosis Vitamin D 27 orang (81.8%). Ditemukan korelasi negatif signifikan kadar 25 (OH) vitamin D total dengan kadar procalcitonin (r = - 0.434, p = 0.012). Kesimpulan : Pada penelitian dapat disimpulkan bahwa 81.8% dari pasien sepsis yang dirawat di ICU mengalami hipovitaminosis Vitamin D. Terdapat korelasi negatif antara kadar 25 (OH) vitamin D dan peningkatan kadar procalcitonin pada pasien sepsis yang dirawat di ICU.