Asosiasi Antara Pemberian Ekstrak Ophiocephalus Striatus Terhadap Kadar Carnosine Dipeptidase-1 (CNDP-1) pada Pasien Kaheksia Kanker

Abstract

Background: The most common manifestation of advanced cancer stage is metabolic symptoms called cancer kaheksia. Cancer cancer is anorexia-kahexia cancer (cancer of anorexia-cachexia syndrome / CACS). Decreased Carnosine Dipeptidase-1 levels in cancer kahexia patients correlated with cancer kahexia parameters associated with poor prognosis. Material and Methods: The study was conducted on 29 cancer patients with clinical trials using one group pre-post test method by measuring Carnosine Dipeptidase-1 levels before and completing Ophiocephalus Striatus administration. The research was carried out in all network hospitals of the Department of Internal Medicine, Faculty of Medicine in the Universitas Sumatera Utara with the approval of the Faculty Medicine Research Ethics Commission, held from January to June 2019. Results: This study was attended by 30 respondents who met the inclusion criteria. As many as 66.7% were men with an average age of 51.47 years. The majority of respondents had gastrointestinal cancer of 46.7%, followed by Lung Carcinoma 20%, Nasopharyngeal Carcinoma by 13.3%, Non Hodgkin Lymphoma in the amount of 6.7% and other cancers13.3%. The Wilcoxon test found a significant relationship between Carnosine Dipeptidase-1 before and after therapy using Ophiocephalus Striatus (p = 0.007). The increase in the value of Carnosine Dipeptidase-1 before treatment was 2.21 μg / mL to 2.8 μg / mL. Conclusion: Carnosine Dipeptidase-1 levels before and after Ophiocephalus Striatus administration in Kaheksia Cancer patients were significantly associated.

Latar Belakang: Manifestasi paling umum dari kanker stadium lanjut adalah gejala-gejala metabolik disebut kaheksia kanker. Kaheksia kanker adalah sindroma anoreksia-kaheksia kanker (cancer anorexia-cachexia syndrome/ CACS). Penurunan kadar Carnosine Dipeptidase-1 pada pasien kaheksia kanker yang berkorelasi dengan parameter kaheksia kanker yang terkait dengan prognosis yang buruk. Desain Penelitian: Penelitian dilakukan pada 29 orang kaheksia kanker dengan uji klinis dengan dengan menggunakan metode pre-post test one group dengan pengukuran kadar Carnosine Dipeptidase-1 sebelum dan sesudah pemberian Ophiocephalus Striatus. Penelitian dilaksanakan di seluruh rumah sakit jejaring Departemen Ilmu Penyakit Dalam FK USU Medan dengan persetujuan Komisi Etik Penelitian FK USU, dilaksanakan mulai bulan Januari-Juni 2019. Hasil: Penelitian ini diikuti oleh 30 orang responden yang telah memenuhi kriteria inklusi. Sebanyak 66,7% adalah laki-laki dengan rerata umur 51,47 tahun. Mayoritas responden memiliki jenis kanker saluran cerna adalah sebanyak 46,7%, diikuti Karsinoma Paru 20%, Karsinoma Nasofaring sebanyak 13,3%, Non Hodgkin Limfoma yaitu sebanyak 6,7% dan kanker jenis lain13,3%. Dengan uji Wilcoxon dijumpai hubungan signifikan Carnosine Dipeptidase-1 sebelum dan setelah terapi menggunakan Ophiocephalus Striatus (p=0,007). Peningkatan nilai Carnosine Dipeptidase-1 sebelum diterapi yakni 2,21 μg/mL menjadi 2,8 μg/mL. Kesimpulan: Kadar Carnosine Dipeptidase-1 sebelum dan sesudah pemberian Ophiocephalus Striatus pada pasien Kanker Kaheksia adalah berhubungan secara signifikan.