Penilaian MPV dan Agregasi Trombosit pada Penderita Diabetes Mellitus Tipe 2

Abstract

Background: Diabetes mellitus patients often have hypercoagilable blood, as evidenced by the increased coagulation, impaired fibrinolysis, endothelial dysfunction and platelet hyperactivity. Hyperactive platelet is a major determinant of prothrombotic state in DM. By assessing MPV and platelet aggregation, which is a marker of platelet activity, in patients with type 2 DM, is expected to help predict acute events. Objective : This research aims to know the differences of MPV and aggregation platelet between poor glycemic control and good glycemic control group in type 2 DM patients. Methods: This cross sectional study was conducted in 22 people with good glycemic control and 28 people with poor glycemic control from June to August 2013. Fasting blood samples were analyzed for CBC, HbA1c, TG and platelet aggregation. MPV and platelet aggregation value were compared between groups using independent t test. Results: there is no significant difference in MPV and platelet aggregation between groups (p=0,598, p=0,464 (1µM), p=0,868 (2µM), p=0,984 (5µM), p=0,401 (10µM)). MPV correlate significantly with platelet aggregation at 1µM and 5µM ADP concentration in good glycemic control group (r=0,591; p=0,004 at 1µM ADP dan r=0,521; p=0,013 at 5µM ADP). MPV correlate significantly with platelet aggregation at 2µM ADP concentration in poor glycemic control group (r=0,405; p=0,033). Conclusion: There was significant differences in MPV and platelet aggregation between groups, but there is a significant correlation between MPV and platelet aggregation in good glycemic control type 2 DM group.

Objektif: Mengetahui perbedaan nilai MPV dan aggregasi trombosit pada penderita DM tipe 2 terkontrol dan tidak terkontrol. Metode: Penelitian dilakukan secara potong lintang pada 22 orang penderita DM tipe 2 terkontrol dan 28 orang penderita DM tipe 2 tidak terkontrol periode Juni hingga Agustus 2013. Sampel darah puasa diperiksa darah lengkap, HbA1c, TG, dan aggregasi trombosit. Hasil: Nilai MPV pada kelompok DM tipe 2 terkontrol dan tidak terkontrol tidak berbeda bermakna (p=0,598), begitu juga nilai aggregasi trombosit dengan konsentrasi ADP 1µM, 2µM, 5µM, dan 10µM, dengan nilai p secara berurutan p=0,464, p=0,868, p=0,984 dan p=0,401. MPV berkorelasi bermakna dengan aggregasi trombosit di konsentrasi ADP 1µM dan 5µM pada kelompok DM tipe 2 terkontrol (r=0,591; p=0,004 untuk ADP 1µM dan r=0,521; p=0,013 untuk ADP 5µM). MPV berkorelasi bermakna dengan aggregasi trombosit di konsentrasi ADP 2µM pada kelompok DM tipe 2 tidak terkontrol (r=0,405; p=0,033). Kesimpulan: Tidak dijumpai perbedaan bermakna antara nilai MPV dan aggregasi trombosit pada kelompok DM tipe 2 terkontrol dibanding tidak terkontrol. Terdapat hubungan bermakna antara MPV dengan aggregasi trombosit pada kelompok DM tipe 2 terkontrol.