Hubungan Kadar Gamma Glutamyltransferase dan Kecepatan Hantaran Saraf pada Penderita Neuropati Diabetik

Abstract

Background : Diabetic neuropathy is one of the common complication of diabetes mellitus (DM). The pathophysiology of diabetic neuropathy includes several factors such as metabolic, vascular, oxidative stress and neurohormonal growth factor deficiency and recent studies have suggested the use of serum gamma-glutamyltransferase (GGT) as an early marker of oxidative stress. Methods : We assessed 24 patient with diabetic neuropathy were diagnosed by anamnesa, physical examination and neurological examination including nerve conduction velocities. We evaluated the association between serum GGt and nerve conduction velocities. Results: A total of 14 women and 10 men were studied; mean age was 57,48 ± 9,41years, mean duration of diabetes was 8,39 ± 3,702 years, mean GGT was 39,17 ± 14,73 UI/L, mean motoric NCV was 39,07 ± 9,45 m/s and mean sensoric NCV was 33,30 ± 8,66 m/s. Conclusion : This study show that levels of serum GGT have inverse correlation with motoric and sensoric nerve conduction velocities.

Latarbelakang : Neuropati diabetik merupakan salah satu komplikasi yang sering dari Diabetes Mellitus (DM). Patofisiologi dari neuropati diabetik terdiri dari beberapa faktor yaitu metabolik, vaskular, stres oksidatif dan neurohormonal growth factor dan studi terbaru menduga serum gamma-glutamyltransferase (GGT) sebagai marker awal stres oksidatif. Metode : Kami memeriksa 24 penderita neuropati diabetik yang didiagnosa berdasrkan anamnesa, pemeriksaan fisik dan pemeriksaan neurologi serta memeriksa kecepatan hantran saraf. Kami mengevaluasi hubungan kadar GGT dengan kecepatan hantaran saraf. Hasil : dari total 14 wanita dan 10 pria ditemukan; rerata usia 57,48 ± 9,41 tahun, rerata lama menderita diabetes 8,39 ± 3,702 tahun, rerata kadar GGT 39,17 ± 14,73 UI/L, rerata nilai KHS motorik 39,07 ± 9,45 m/s dan rerata nilai KHS sensorik 33,30 ± 8,66 m/s. Kesimpulan : Studi ini menunjukkan kadar GGT mempunyai korelasi negative dengan KHS sensorik dan motorik.