Hubungan Kadar Hemoglobin Glikosilat dan N-Terminal Probrain Natriuretic Peptide dengan Outcome pada Pasien Stroke Iskemik Akut

Abstract

Background: Acute ischemic stroke accounts for approximately 70% of all strokes, and is caused by embolic or atherosclerotic occlusion in the cerebral vessels. Hemoglobin glycosylate (HbA1c) and NT-proBNP level on admission were associated with outcomes after acute ischemic stroke. Purpose: The objective of this study was to determine the relationship between HbA1c and plasma NT-proBNP with outcome in acute ischemic stroke patients. Methods: Thirty-seven consecutive acute ischemic stroke patients who fulfilled the criteria were included. The HbA1c and NT-proBNP were tested in each patients. We investigated the relationship between HbA1c and NTproBNP with outcomes. Clinical outcome was measured on admission and on day 14 after treatment using National Institude Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS). Results: In this study we used Spearman correlation test. There was significant strong positive relationship between HbA1c with NIHSS H-1(r = 0.695, p = 0,000) and HbA1c with NIHSS H-14 (r = 0.689, p = 0,000) also HbA1c with mRS H-1 (r = 0.537, p = 0,000) and HbA1c with mRS H-14 (r = 0.694, p = 0,000). And There was significant strong positive relationship between NT-proBNP with NIHSS H-1(r = 0.626, p = 0,000) and NTproBNP with NIHSS H-14 (r = 0.696, p = 0,000) also NT-proBNP with mRS H-1 (r = 0,533, p = 0,000) and NT-proBNP with mRS H-14 (r = 0.703, p = 0,000). Conclusion: There were strong positive correlation between HbA1c and NT-proBNP with outcome in acute ischemic stroke patients.

Latar Belakang: Stroke iskemik akut menyumbang sekitar 70% dari semua stroke, dan disebabkan oleh oklusi embolik atau aterosklerotik pada pembuluh serebral. Tingkat hemoglobin glikosilat (HbA1c) dan NTerminal pro Brain Natriuretic Peptide (NT-proBNP) saat masuk dikaitkan dengan outcome setelah stroke iskemik akut. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara HbA1c dan NT-proBNP dengan outcome pada pasien stroke iskemik akut. Metode: Tiga puluh tujuh pasien stroke iskemik akut yang memenuhi kriteria diikutsertakan dalam penelitian ini. Kadar HbA1c dan NT-proBNP diuji pada setiap pasien. Kami menyelidiki hubungan antara HbA1c dan NT-proBNP dengan outcome yang diukur pada saat masuk dan pada hari ke 14 setelah perawatan menggunakan National Institude Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS). Hasil: Penelitian ini menggunakan uji korelasi Spearman. Terdapat hubungan positif kuat yang signifikan antara HbA1c dengan NIHSS H-1 (r = 0,695, p = 0,000), HbA1c dengan NIHSS H-14 ( r = 0,689, p = 0,000) dan juga HbA1c dengan mRS H-1 (r = 0,537, p = 0,000), HbA1c dengan mRS H-14 (r = 0,694, p = 0,000). Dan terdapat hubungan positif kuat yang signifikan antara NT-proBNP dengan NIHSS H-1 (r = 0,626, p = 0,000) dan NT-proBNP dengan NIHSS H-14 (r = 0,696, p = 0,000) juga NT-pro BNP dengan mRS H-1 (r = 0,533, p = 0,000) dan NT-proBNP dengan mRS H-14 (r = 0,703, p = 0,000). Kesimpulan: Terdapat korelasi positif kuat yang signifikan antara HbA1c dan NT-proBNP dengan outcome pada pasien stroke iskemik akut.