Perbandingan Nilai AGDA, Elektrolit dan Laktat Setelah Pemberian Ringer Asetat Malat Dengan Ringer Laktat Untuk EGDT Pasien Sepsis

Abstract

Background And Objective : Sepsis is the second highest death caused at intensive care unit and the 10 highest death caused all over the world. According to Survival Sepsis Campaign 2012, the early management for sepsis patients is 30 ml/kg crystalloid. In this study, we compared the best type of crystalloid for resuscitation or EGDT for patients. Method: This study is a double blind randomized clinical trial, which starts from December 2016-January 2017 at Haji Adam Malik General Hospital Medan. The changes before and after fluid resuscitation of AGDA, electrolyte (Sodium, Phosphate and Chloride) and lactate are observed on 40 potentially eligible patients. Result: From 40 sepsis patients who undergo this study, the comparison of ringer acetate malate and ringer lactate was observed. There is an improvement of AGDA result on HCO3 ( p = 0,001), TCO2 ( p = 0,002) , BE (p = 0,048). While on electrolyte results, there is a decreasing value for sodium ( p= 0,149). There is a better result on lactate by administering ringer acetate malat ( p < 0,001). The administration of ringer acetate malate gives higher value for AGDA, sodium and lactate compared to ringer lactate. Conclusion:. The administration of ringer acetate malate on EGDT for sepsis patient is better in maintaining acid-base equilibrium on the body compared to ringer lactate.