Kadar Hs-Crp Pada Pasien DM Tipe 2 dengan dan Tanpa Hipertensi

Abstract

1.Clinical Phatology Department, Medical School, Sumatera Utara University/H. Adam Malik Hospital, Medan, 2. Endocrinology Division, Internal Medicine Department, Medical School of Sumatera Utara University/ H. Adam Malik Hospital, Medan. Introduction: More than 50% of patients with type-2 diabetes have hypertension. Hypertension contributes the development of cardiovascular disease. hs-CRP is an inflammation marker which is associated with cardiovascular risk. The aim of this study is to measure hs-CRP in type-2 diabetes with and without hypertension and to assess hs-CRP levels based on cardiovascular risk group. Methods: This study is an analytical observational cross-sectional study. Performed at the Department of Clinical Pathology Adam Malik Hospital, the total of type-2 DM subjects with and without hypertension is 56, with 28 in each group. Laboratory tests: complete blood count, blood sugar levels, HbA1C, SGOT, SGPT, Lipid Profile, hs-CRP. Results: There was significant differences in the average levels of hs-CRP in type-2 diabetic patients with hypertension (4.03±2.49) and without hypertension (1.98 ± 1.93), p = 0.001. Pearson correlation test showed a significant association of hs-CRP towards total cholesterol and HDL in both groups and a significant difference in cardiovascular risk group, p= 0.001. Discussion: hs-CRP levels were higher in type-2 diabetes with hypertension and associated with the risk of cardiovascular disease. Conclusion: There are significant differences between the levels of hs-CRP type- 2 diabetes with and without hypertension.

Pendahuluan: Lebih 50% penderita DM tipe-2 mengalami hipertensi. Hipertensiberkontribusi terhadap berkembangnya penyakit kardiovascular. hs-crp sebagai marker inflamasi berkaitan dengan resiko kardiovaskular. Penelitian bertujuan mengukur hs-CRP pada subjek DM tipe-2 dengan dan tanpa hipertensi dan melihat perbedaan kadar hs-CRP berdasarkan kelompok resiko kardiovaskular. Metode: Penelitian ini bersifat analitik observasional dengan pendekatan potong lintang. Dilakukan di Departemen Patologi Klinik RSUP H. Adam Malik Medan, terhadap 56 sampel DM-tipe 2, dengan dan tanpa hipertensi masing-masing 28 orang. Dilakukan pemeriksaandarah lengkap, KGD, HbA1C, SGOT, SGPT, Lipid Profile, hs-CRP. Hasil: Didapati perbedaan signifikan rata-rata kadar hs-CRP penderita DM tipe-2 dengan Hipertensi (4,03±2,49) dan tanpa hipertensi (1,98±1,93), p=0.001. Uji korelasi Pearson menunjukkan hubungan signifikan hs-CRP dengan totalkolesterol dan HDL pada kedua kelompok. Dijumpai perbedaan signifikan kadar hs-CRP berdasarkan kelompok resiko kardiovaskular p=0,001. Pembahasan: Kadar hsCRP lebih tinggi pada DM tipe-2 dengan hipertensi dan berkaitan dengan resiko penyakit kardiovaskular. Kesimpulan: Terdapat perbedaan bermakna kadar hs-CRP antara DM tipe-2 dengan dan tanpa hipertensi.