Analisis Kadar Glial Fibrillary Acidic Protein Dengan Tingkat Keparahan Cedera Kepala di RSUP. H. Adam Malik

Abstract

Objective: This study was to determine the relationship of serum GFAP levels with severity of head injury patients. Methods: This study is an analytical study using cross-sectional methods. The study lasted from June 2013 until March 2014 in Adam Malik General Hospital. And severe head injury patients were included in the study if the onset is less than 48 hours. Selected patients were evaluated based on the findings of the CT scan of the head. The patient was taken to the sampling concecutive way, then blood samples were taken for examination and inspection GFAP serum GFAP cumulative. Results: The results showed that GFAP levels associated significantly with GCS after resuscitation (r = -0.631, p = 0.0001). The correlation is a negative correlation (r = -0.631, p = 0.0001). If the higher GCS after resuscitation, serum GFAP levels will be even lower. Conclusions: Levels of GFAP severe head injury patients (11.9 ± 10.52) was significantly higher compared to patients with moderate head injury (1.82 ± 1.60, p = 0.0001). There is a significant correlation between serum GFAP levels with initial GCS after resuscitation (r = -0.631, p = 0.0001).

Tujuan: Studi ini Metode: Penelitian ini merupakan studi analitik yang menggunakan metode cross sectional. Penelitian ini berlangsung dari Juni 2013 sampai Maret 2014 di Rumah Sakit Umum Adam Malik. Pasien cedera kepala berat dan sedang dilibatkan dalam penelitian ini jika onset kurang dari 48 jam. Pasien yang dipilih dievaluasi berdasarkan pada temuan CT scan kepala. Pasien diambil dengan cara concecutive sampling, kemudian dilakukan pengambilan sampel darah untuk pemeriksaan GFAP dan dilakukan pemeriksaan GFAP serum kumulatif. untuk mengetahui hubungan kadar GFAP serum dengan tingkat keparahan penderita cedera kepala. Hasil: Hasil penelitian menunjukkan bahwa kadar GFAP berhubungan signifikan dengan GCS setelah resusitasi (r=-0,631, p=0,0001). Korelasi yang terjadi merupakan korelasi negatif(r=-0,631, p=0,0001). Jika GCS setelah resusitasi semakin tinggi, kadar GFAP serum akan semakin rendah. Kesimpulan: Kadar GFAP penderita cedera kepala berat (11,9±10,52) lebih tinggi secara signifikan dibandingkan penderita cedera kepala sedang (1,82±1,60, p=0,0001). Terdapat korelasi yang signifikan antara kadar GFAP serum dengan GCS awal setelah resusitasi (r=-0,631; p=0,0001).