Hubungan Kadar Asam Urat Serum Penderita Psoriasis Vulgaris dengan Skor Psoriasis Area and Severity Index

Abstract

Background Psoriasis is a chronic inflammatory disease of the skin which is characterized by hyperproliferation of keratinocytes. The etiology of psoriasis has not been completely understood, however it seems that factors like genetics, surroundings, hormones, and disorder of body metabolism contribute to the occurence of this disease. There is a hypothesis that suggests serum uric acid levels may affect the turn over of epidermis so that it can be involved in the pathogenesis of psoriasis. Obective To understand the relation between serum uric acid levels of psoriasis vulgarispatients with the score of Psoriasis Area and Severity index(PASI). Method Twenty five patients with psoriasis vulgaris that came for treatment to the polyclinic of Dermatology and Venereal Diseases H.Adam Malik Central General Hospital Medan were participated in this research. History taking and clinical examination were done. The severity degree of psorisis was measured using the score of PASI. The examination of serum uric acid levels was performed using uricase methods. Result There was a moderate positive correlation between serum uric acid levels and the score of PASI (r=0,593;P=0.002). Conclusion There is a significant relation between serum uric acid levels and the score of PASI

Latar belakang Psoriasis adalah penyakit peradangan kulit kronik yang ditandai dengan hiperproliferasi keratinosit.Etiologi psoriasis belum dimengerti sepenuhnya, namun tampaknya faktor genetik, lingkungan, hormonal dan kelainan metabolisme tubuh berperan pada terjadinya penyakit ini. Terdapat hipotesis yang menyatakan kadar asam urat serum dapat mepengaruhi turn over epidermis sehingga dapat terlibat dalam patogenesis psoriasis. Tujuan Untuk mengetahui hubungan antara kadar asam urat serum pada penderita psoriasis vugaris dengan skor Psoriasis Vulgaris dengan Skor Psoriasis Area and Severity index(PASI). Metode Dua puluh lima orang pasien psoriasis vulgaris yang berobat ke poliklinik Ilmu Kesehatan Kulit dan Kelamin RSUP.H.Adam Malik Medan diikutsertakan dalam penelitian ini. Dilakukan anamnesis dan pemeriksaan Klinis.Derajat keparahan psorisis diukur dengan menggunakan skor PASI. Pemeriksaan kadar asam urat serum dilakukan dengan menggunakan metode urikase. Hasil Terdapat korelasi yang positif sedang antara kadar asam urat serum dengan skor PASI (r=0,593;P=0.002). Kesimpulan Terdapat hubungan yang signifikan antara kadar asam urat serum dengan skor PASI.