Hubungan Kadar Vitamin D dengan Derajat Keparahan Pasien Covid-19 yang Dirawat Di RSUP Haji Adam Malik Medan

Abstract

Background: The COVID-19 pandemic has caused a global health crisis around the world. Until now, only a few studies have been conducted and few protective factors can play a role in infection with the SARS COV-2 virus. Vitamin D is said to have an important role in reducing the risk of COVID-19 infection and other acute respiratory infections in a person. In the case of SARS – COV – 2 infection, vitamin D is said to suppress viral replication directly, and is also effective in enhancing anti-inflammatory and immunomodulatory processes in the body. Objective: To determine the relationship between vitamin D levels and the severity of COVID-19 patients at Haji Adam Malik General Hospital, Medan. Hypothesis: There is a relationship between vitamin D levels and the severity of COVID-19 patients at Haji Adam Malik General Hospital in Medan. Methods: The research was conducted at the Clinical Pathology Laboratory, H. Adam Malik Hospital, Medan. Samples were collected by consecutive sampling on patients diagnosed with COVID-19 at Haji Adam Malik General Hospital Medan from November 2021 to March 2022 who met the inclusion and exclusion criteria. A total of 34 patients were divided into three groups, namely the COVID- 19 patient group with moderate, severe and critical degrees. Results: By using the Kruskal Wallis test to assess the relationship between vitamin D levels and the severity of COVID-19 patients at Haji Adam Malik Hospital Medan, the p value = 0.467. This shows that there is no significant relationship between vitamin D levels and the severity of COVID-19 patients at Haji Adam Malik Hospital in Medan. Conclusion: There is no significant relationship between vitamin D levels and the severity of COVID-19 patients.

Latar belakang: Pandemi COVID – 19 telah menyebabkan krisis kesehatan global di seluruh dunia. Hingga saat ini baru sedikit penelitian yang sudah dilakukan dan sedikit faktor protektif yang dapat berperan dalam infeksi virus SARS COV – 2. Vitamin D dikatakan memiliki peranan penting dalam menurunkan risiko infeksi COVID – 19 maupun infeksi saluran pernafasan akut lain pada seseorang. Pada kasus infeksi SARS – COV – 2, vitamin D dikatakan dapat menekan replikasi virus secara langsung, dan juga efektif dalam meningkatkan proses anti inflamasi dan imunomodulator dalam tubuh. Tujuan : Untuk mengetahui hubungan kadar vitamin D dengan derajat keparahan pasien COVID – 19 di RSUP Haji Adam Malik Medan. Hipotesa : Ada hubungan kadar vitamin D dengan derajat keparahan pasien COVID – 19 di RSUP Haji Adam Malik Medan. Metode: Penelitian dilakukan di Laboratorium Patologi Klinik RSUP H. Adam Malik Medan. Pengumpulan sampel dilakukan secara consecutive sampling pada pasien yang terdiagnosa COVID – 19 di RSUP H. Adam Malik Medan mulai dari November 2021 hingga Maret 2022 yang memenuhi kriteria inklusi dan eksklusi. Sebanyak 34 pasien yang dibagi kedalam tiga kelompok yaitu kelompok pasien COVID – 19 derajat sedang, derajat berat dan derajat kritis. Hasil : Dengan menggunakan uji Kruskal Wallis untuk menilai hubungan kadar vitamin D dengan derajat keparahan pasien COVID – 19 di RSUP Haji Adam Malik Medan diperoleh nilai p=0,467. Hal ini menunjukkan tidak terdapat hubungan yang signifikan antara kadar vitamin D dengan derajat keparahan pasien COVID – 19 di RSUP Haji Adam Malik Medan. Kesimpulan : Tidak terdapat hubungan yang signifikan antara kadar vitamin D dengan derajat keparahan pasien COVID – 19.