Perbandingan Efektifitas Tetes Mata Fluorometholon 0,1% dengan Tetes Mata NaCl-KCl terhadap Sindroma Mata Kering pada Pasien Diabetes Melitus

Abstract

lntroduction : Dry eye syndrome is a multifactorial disease which is marked by lipid, aquous,and mucin defficiency. Treatment for dry eye syndrome patient usually use artificial tear containing NaCl-KCl. ln chronic condition, corticosteroid give better performance to increase goblet cell density, mucin quality and improve mild-severe dry eye syndrome. Methods ; This is experimental study with single blind clinical trial. Sixty patients diabetes melitus patient lype 2 are appropriate with inclusion and exclusion criteria involve as the sample, then undergo schirmer land ferning test. They were randomly assigned to fluorometholon or Nacl treatment group. Both of these groups are given the same dosage (4xgtt l) then be evaluated in day 0,14 and 30. Result : After 30 days treatment, schirmer I and ferning of NaCl group improved about 23.3% whereas the group that receive fluorometholon 0.1% improves about 60%. Statistically, fluorometholon 0.1% are significantly effective in improving ocular surface (P=0.016). Conclution : Treatment using topical 0.1% fluorometholon provided faster improvement in ocular surface disease for diabetic mellitus type 2 patients with dry eye compared with topical NaCl-KCl.