Perbedaan Kadar Kolesterol Total pada Laki-Laki dengan Skizofrenia yang Mendapat Pengobatan Risperidon dan Haloperidol di Instalasi Rawat Inap Rumah Sakit Jiwa Prof. Dr. M.Ildrem.Medan

Abstract

Background: Cholesterol is a fat-like substance in the cell membrane and is a precursor of bile acid and steroid hormones. Changes in membrane lipid metabolism are other aspects of lipid biology that are suggested to be involved in the pathophysiology of schizophrenia. Anti-psychotic drugs affect cholesterol levels in the body,. Objective: To determine the difference in total cholesterol levels in men with schozophrenia who get risperidone and haloperidol. Method:. This study is an experimental, unpaired numerical comparative analytic study to assess differences in total cholesterol levels in men with schizophrenia who received risperidone and haloperidol treatment for 8 weeks Results: There was a very significant difference in total cholesterol levels in men with schizophrenia between the group receiving risperidone and the group receiving haloperidol at week 8. p <0.001 Conclusion: There was a significant increase in total cholesterol levels in people with schizophrenia who received risperidone treatment compared with haloperidol.