Pengaruh Pemakaian Prednison pada Anak dengan Sindrom Nefrotik terhadap Peningkatan Tekanan Intra Okular

Abstract

Background: Nephrotic syndrome is a kidney disease which common happen to children in Indonesian. In nephrotic syndrome, antibiotic and steroid could decrease mortality this disease in drastis. Meanwhile using kortikosteroid could causes eye disorder that is increasing of intra ocular pressure. Objective: The purposes of this research is to evaluate the intra ocular pressure effects of using prednisone in children with nephrotic syndrome. Method: This research using prospective study. The intra ocular pressure of 20 children with nephrotic syndrome were measured in three times. The first measure before using prednisone therapy. The second measure after of prednison therapy that is lourth -in the first week with 2 mg/kg/day and the last examination fourth in the second week with 1,5 mg/kg of alternating day. Result: There is no correlation between elevation of intra ocular pressure with age and dosage of prednisone in nephrotic syndrome who doing prednisone therapy. However there is correlation between elevation of intra ocular pressure with usage of prednisone in nephrotic syndrome (t = 0,031 with p< 0,05). Conclusion: Effect of prednisone for long periods can affect the elevation of intra ocular pressure.