Perbandingan Kadar Marker Koagulasi antara Penderita Stroke Iskemik Akut dan Stroke Hemoragik Akut

Abstract

Background : Stroke is a leading cause of death and long-term disability worldwide that includes various pathophysiological entfties that include thrombosis, hemorrhage and embolism. Diagnosis currently relies on the stroke clinical examination the doctor and was further supplemented with various neuroimaging techniques. There have been studies on employing some laboratory markers besides advanced radiologic methods in differential diagnosis of ischemic and hemorrhagic stroke. Homeostatic abnormalities could be a result of brain injury more than primary activation of system during acute phase of ischemic or hemorrhagic stroke. Objective: To compare the levels of markers of coagulation in patients with acute ischemic stroke and acute hemorrhagic stroke. Methods : This study is a cross-sectional study conducted on patients who seek treatment at the Department of Neurology H. Adam Malik Medan. All subjects were examined levels of markers of coagulation such as D-dimer, fibrinogen, aPTT, PT and JNR. Test results were analyzed by statistical analysis using Chi-square. Results : Of the 74 research subjects consisted of 37 subjects with acute ischemic stroke patients and 37 people who had acute hemorrhagic stroke. Male totaled 43 people (58.1%) and 31 women (41.9%). Average age of subjects was 57,50±12,51 years old. All subjects did not differ in terms of

demographic characteristics. There were no differences in the levels of D- dimer, fibrinogen, aPTT, PT and INR (respectively p = 0.480, p = 0.582, p =

0.888, p = 0.100, p = 0.982) were significant among patients with acute ischemic stroke and acute hemorrhagic stroke. Conclusion : There were no differences in levels of markers of coagulation between acute ischemic stroke and acute hemorrhagic stroke.