APTT dan Fibrinogen pada Pasien Sindrom Nefrotik Anak saat Relaps dan Remisi

Abstract

Background: Nephrotic syndrome is a complicated kidney disease disorder, one of the most important complications of which is thromboembolism which can affect the circulation, either arterial or venous in both pediatric and adult patients. Patients at risk of thromboembolism should have an angiogafi examination for diagnosis. There have been several studies conducted on patients with nephrotic syndrome that show the risk of thromboembolism. Method : The study included twelve patients of childhood nephrotic syndrome consisting of men and women. The patient experiences a period of relapse and becomes a remission. Patients participating in the study were 3 to 1 7 years old. Result and discussion : There were significant differences in fibrinogen in which the fibrinogen content of SN patients in children at relapse was higher compared with the time of remission (390.08 ± 164.87 vs 273.17 ± 150.56; p = 0.042). There was no significant difference in APTT results in SN patients in relapse compared to remission (34.17 ± 5.65 vs 30.08 ± 8.49; p = 0.236). The high levels of fibrinogen in the relapse period indicate the presence of hypercoagulable state, along with other examinations such as high cholesterol and low albumin. Conclusion and suggestion : In this study there was no significant difference of APTT among SN patients during relapse compared with remission while in fibrinogen examination found significant difference. Therefore, fibrinogen examination is important to be analyzed in order to avoid SN complications.