Korelasi antara Ekspresi Nucleus Factor Kappa B (NFKB) dan Microvessel Density (MVD) pada Karsinoma Nasofaring di RSUP H. Adam Malik Medan

Abstract

lntroduction : Nasopharyngeal Carcinoma (NPC) is a malignant tumor that arise from the nasopharynx. Globally, according to WHO, patient with NPC were found 65.000 new cases and 38.000 deaths each year in 2000. ln lndonesia we found 10.000 new cases each year. Since Nuclear Factor Kappa B (NFkB) was found in 1986, many research show this transcription factor plays a role in NPC development, which are the tumor growth, metastasis and also the turnor stage by various pathway, and one of those signaling pathway is angiogenesis Purpose: To determine the correlation between Nucleus Factor Kappa B (NFkB)expression and Microvessel Density (MVD) ln patients with nasopharyngeal carcinoma in H. Adam Malik General Hospital Method: This research was a cross sectional study. lt was conducted in H. Adam Malik General Hospital and Pathological Anatomy division of Medical Faculty of University of Sumatera Utara on October 2014 to March 2015 by using 30 NFC samples. Result: There are a strong positive correlation between the expression of NFkEi and MVD against Tumor size, lymph nodes metastases, and tumor stage in NPC patients.