Hubungan Sindrom Metabolik dengan Kejadian Overactive Bladder pada Perempuan Menopause di Kabupaten Deli Serdang

Abstract

Background. Overactive bladder syndrome (OAB) is often undiagnosed in postmenopausal women, even though it can affect the patient's psychological, quality of life, and physical condition. One of the factors thought to increase the risk of OAB is metabolic syndrome. This study aims to find the relationship between OAB and metabolic syndrome. Methods. A case-control study was conducted with 25 postmenopausal women with OAB in cases group and 25 women without OAB in control group in Deli Medium, April–May 2021. OAB was assessed by using the OABSS questionnaire and urinalysis. Metabolic syndrome was assessed by measuring waist circumference, triglyceride levels, HDL, blood pressure, and fasting blood glucose. The data were then analyzed descriptively and analytically using appropriate statistical tests. Results. There were no differences in age, parity, duration of menopause, history of hysterectomy, and smoking in the two groups (p>0.05). The proportion of obesity was higher in the case group (80% vs 44%) (p=0.003). In the case group, 64% of the subjects experienced mild severity (score <5). Blood pressure was associated with OAB (p<0.05). Metabolic syndrome increased the risk of OAB (OR 8.5 (95% CI 2.3–30.9); p=0.002). Discussion. Sympathetic neuroinflammation, proinflammatory cytokines, oxidative stress, and bladder endothelial dysfunction in the metabolic syndrome can trigger the impaired contractions and increase bladder overload, which causing OAB. Conclusion. There is a significant relationship between metabolic syndrome and OAB.