D-Dimer dan Fibrinogen pada Pasien-Pasien yang Menjalani Tindakan Pembedahan pada Tumor Ovarium Ganas dan Jinak

Abstract

Background Ovarian tumour ranks second in gynecology tumour cases and ranks second in gynecology tumour death in Indonesia Tumour cause hypercoagulable that increase risk of thrombosis by procoagulant mechanism. Tumour cells also can cause hyperfibrinogenemmia that can cause bleeding. The aim of study was to know D-dimer and fibrinogen value to investigate primary hyperfibrinolysis on malignant and benign ovarian tumour; and to know whether operation procedure on malignant and benign tumour change D-dimer and fibrinogen value. Method Prospective analysis study, subject were malignant and benign ovarian tumour patients undergoing surgery in Haji Adam Malik Hospital, Medan One way Annova test dan Wilcoxon Sum-Rank test were performed. Statistical differentiation is indicate with p<0,05. Result and Discussion Study subject was 16 patient where I malignant and benign ovarian tumour patient respectively. Malignant ovarian tumour D-dimer values was higher than benign ovarian tumour (p<0,01) that indicate fibrinolysis increase in malignant ovarian tumour. Malignant ovarian tumour fibrinogen values as same as benign ovarian tumour (p>0,05) that indicate the fibrinolysis in ovarian tumour wasn't primary hyperfibrinolysis. Conclusion Surgery procedure didn't influence D-dimer and fibrinogen values. Primary hyperfibrinolysis wasn't occur in ovarian tumour.