Perbedaan Ekspresi Imunohistokimia Matriks Metalloproteinase-7 (MMP-7) dan Vascular Endothelial Growth Factor (VEGF) pada Ovarium Normal, Kista Ovarium Jinak, dan Kanker Ovarium

Abstract

Background : MMP7 acts as a specific signal of cancer cells in the stromal cell component necessary for tumor angiogenesis. VEGF is the main regulator of angiogenesis that promotes cell survival, proliferation, and endothelial cell migration while increasing vascular permeability. VEGF is also involved in the pathogenesis of ovarian cancer. Objective : To investigate the association of MMP7 and VEGF expression with ovarian cancer, benign ovarian cysts, and normal ovaries. Method : This study was analytical research with case control design. In the study, immunohistochemical expression of MMP7 and VEGF was carried out on paraffin block of ovarian cancer tissue, benign ovarian cyst, and normal ovary. Result: In 40 subjects with ovarian tumors, 17 patients (42.5%) were found with positive MMP7 expression. In the control group, no subjects were found with positive MMP7 expression. Using Fisher's exact test, there was a significant relationship between MMP7 expression and ovarian tumor incidence (p <0.001). Meanwhile, in 40 subjects with ovarian tumors, 21 patients (65%) were found with positive VEGF expression. In the control group, no subjects with positive VEGF expression were found. Spearman correlation test shows that there is significant correlation between MMP and VEGF expression, with correlation value r = 0,482 Conclusion: There is positive correlation between MMP 7 and VEGF, the more stronger the expression of VEGF, the more stronger the expression of MMP7, as well.