Resistensi Aspirin secara Laboratoris pada Perokok dengan Menggunakan Agregasi Platelet

Abstract

Background. Based on framingham study, cigarette smoking cause athe rothrombotic cardiovascular disease (CVD). Aspirin is the most widely used antiplatelet drug in CVD, it reduces the risk of secondary events by about 25% in cardiovascular disease. Lately, it was reported that 5-45%, of these patients are resistant to aspirin. Objective. We aimed to investigate the impact of cigarette smoking on aspirin resistance. Methods. twenty two smokers and 18 non-smokers were enrolled in this study. We required all of 40 subject to take 160 mg of aspirin after the first sample was taken. First Sample was taken in the moring, while second sample was obtained 2 hours after aspirin consumption- Platelet agregation was done using light transmittence aggregometry (LTA). Results. aspirin resistance was found in 2 of 22 smokers (9-09%) and 2 of 18 non-smokers (11.11%). No significant difference (p >0-05) was found from both smokers and nonsmokers either in aggregation before or after taking aspirin. Conclusion. we determined that cigarette smoking does not cause aspirin resistance.