Hubungan Lama Pemakaian Obat Asam Valproat terhadap Berat Badan pada Anak Epilepsi

Abstract

Background: Patients with epilepsy must be treated with longterm anti epileptic drugs. Many long term epileptic drugs have weight gain as side effects. Valproic acid is one of the antiepileptic drugs which can increase body weight. Objective: To determine the relationship of long term usage of valproic acid and body weight in epileptic child Methods: A crossectional study was conducted on Pediatric neurology outpatient clinic Haji Adam Malik Hospital Medan in May - June 2016. Subjects were children aged < 18 years old had epilepsy, using monotherapy antiepileptic drugs for a minimum of a 3 month period. Statistical analysis using x test, with Cl 95%. Significant value was set at P < 0,005 Results: Eighty eight subjects fulfilled the inclusion criteria, 44 were using valproic acid < 1 years and 44 were using valproic acid > 1 years. Children who consumed valproic acid > 1 year will experienced increased weight gain 3,687 times compared to children who consumed valproic acid < 1 year.(PR 3,687; Cl 95% 1,280-10,620; p 0.001), Conclusion: There are a significant relationship of long term usage of valproic acid and increasing of body weight.