Hubungan antara Kadar Estradiol dan Kalsium dengan Kejadian Stroke Iskemik Akut dan Kejadian Hipertensi pada Pasien Wanita dengan Menopause

Abstract

Introduction Estradiol and calcium have different role in mechanism and its level for becoming ischemic stroke event and hypertension are still unclear. The purpose of this study is to know about the level of estradiol and calcium when ischemic stroke event and hypertension happened, and association between them, that are studied in menopause women. Methods This was a cross-sectional study that consist of 3 groups with control, patients with acute ischemic stroke (n= 29), patients with hypertension (n=29), and patients with acute ishemic stroke plus hypertension (n=29). Total sample were drawn with consecutive sampling. All participants, that had fulfil inclusion criteria and didn't have exclusion criteria, were asked to complete questionnaire about demographic data and then the blood was withdrawn to measure estradiol and calcium level. Demographic data would be analyzed using descriptive statistics. To analize association between estradiol and calcium level between 3 groups with control, this study would use Chi Square test and Gamma correlation. A p value < 0. 05 was considered statistically significant. Results Estradiol has an association with acute ischemic stroke significantly in menopausal women with positive correlation (p=0.035, r=0.518), but there is no relationship with acute ischemic stroke plus hypertension (p=0.180) and hypertension events (p=0. 180). Calcium has relationship with acute ischemic stroke event with negative correlation (p=0.012; r=-0.635), and hypertension with negative correlation (p=0. 012; r=-0. 635), but there is no relationship with acute ischemicstroke events (p=0.104). Conclusion There is relationship between estradiol and acute ischemic stroke events with positive correlation and moderately strength (r=0,518) and there is relationship between calcium with acute ischemic stroke events plus hypertension and hypertension events with negative correlation and strongly strength (r=0,635). It is necessary to have further study to know more about the relationship.