Hubungan Serum Feritin dengan Resistensi Insulin yang Diukur dengan HOMA - IR pada Penderita Sindroma Metabolik

Abstract

Introduction. Some theory says the primary cause of metabolic syndrome is insulin resistance. Researchers showed ferritin relationship with metabolic syndrome, insulin resistance and type 2 diabetes mellitus. Ferritin is a catalyst in the formation of free radicals. These free radicals will cause liver damage that impaired insulin degradation. Aim. To see if there is a relationship between the increase in serum ferritin with the development of insulin resistannce. Method. Analytical observational study conducted by the cross sectional . The study was conducted at the Clinical Pathology H.Adam Malik Hospital in Medan. Total sample of 25 people who meet the IDF criteria. Data were analyzed with Pearson correlation statistical test. Results. Research subjects consisted of 15 ( 60%) women and 10 (40%) men. In this study, 13 (52%) had high ferritin, among them 12 ( 85 %) with HOMA-IR > 2,5 (insulin resistance). _Statistically there is a relationship between ferritin with insulin resisten with p <0.0001 and r = 0.764. Also found significant differences between ferritin levels to groups of women and men with p; 0.04. In men found a significant association between ferritin and HOMA-IR with p; 0,042 and r=0,649 while the women found a positive correlation, although not statistically significant p; 0.052 and r = 0.51. Ferritin has a siginificant relationship with fasting blood glucose p; 0.03 and r = 0.68 and was not significantly associated with blood pressure (p; 0. 95), HDL (p; 0. 74) and triglycerides (p; 0:39) . . Conclusion. We Found a significant association between the increase in ferritin with insulin resistance and ferritin with fasting blood glucose. And no significant association between ferritin with blood pressure, HDL and triglycerides.