| dc.description.abstract | Background : Acute ischemic stroke has recently become a common cause of
death and disability in the world. There are some factors that can influence the
outcome of patients with acute ischemic acute. Many authors have
demonstrated a relationship between D-dimer level and stroke progression.
Elevated blood glucose level is common in the early phase of stroke.
Admission hyperglycemia in patients with or without diabetes is associated with
a worst clinical outcome than in patients without hyperglycemia. Large number
of studies have been performed to identify the relationship between uric acid
and stroke, the issue remains unresolved and it is unclear whether uric acid
promotes or protects against stroke. This study aimed to investigate the
correlation between D-dimer, blood glucose, uric acid level with infarct volume
and outcome in acute ischemic stroke patients.
Methods: This study was a cross sectional study of 61 acute ischemic stroke
patients. All patients underwent measurement of serum -levels of D-dimer,
random blood glucose, fasting blood glucose, and uric acid; brain CT Scan to
quantify infarct volume; neurological examination assessed by National
Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS).
Results : The 61 patients with AIS had a mean age of 58 years, 26 (4L,.6%)
were men and 35 (57,4%) were women. The D-dimer levels were significantly
correlated with infarct volume (r=0.381; p=0.02), NIHSS scores (r=0.495;
p=0.0001), and mRS scores at day 14 (r=0.433; p=0.0001). The fasting blood
glucose levels were significantly correlated with infarct volume (r=0. 280;
p=0.029) but not with NIHSS and mRS scores. Uric acid levels 1,vere
significantly correlated with NIHSS scores (r=0.317; p=0.013) and mRS scores
(r=0.281; p=0.028) at day 14, but not with infarct volume. The infarct vo/ume
significantly had a very strong correlation with NIHSS scores (r=0.839;
p=0.0001) and mRS scores (r=0.819; p=0.0001) at day 14. Multivariate analysis
showed that infarct volume alone significantly correlated with outcome in this
acute ischemic stroke patients.
Conclusions : The elevated serum D-dimer and fasting blood glucose level can
be used as a marker for increased the infarct volume. Outcome can be
predicted by level of D-dimer, uric acid and infarct volume. Infarct volume very
strongly correlated with outcome in patient with acute ischemic acute. | en_US |
