Hubungan Luas dan Lokasi Lesi dengan Aspek Fungsi Kognitif Berdasarkan Hasil Mini Mental State Examination dan Clock Drawing Test pada Pasien Stroke Iskemik

Abstract

Background: There is growing recognition that ischemic brain lesions have significant contribution in cognitive impairment. We hypothesized that specific size and location of brain lesion would associated with certain aspects of cognitive function in stroke patients. Purpose: The aim of this study was to assess the association of lesion size and location with aspects cognitive function using Mini Mental State Examination (MMSE) and Clock Drawing Test (CDT) in ischemic stroke patients. Method: This was a cross sectional study of 60 chronic ischemic stroke patients who came to Haji Adam Malik General Hospital. The size and location of brain infarction identified by Head CT scan. Cognitive function were assessed by using MMSE and CDT. Results: Of 60 patients, 34 were males (56. 7%) and 26 were females (43.3%). The largest age group was 50-60 years old (33 subjects, 55.0%). The largest subject according to the size of lesion was 10-30 cm3 (36 subjects, 60,0%). The largest lesion location was in subcortex (32 subjects, 53,3%) and left hemisphere (25 subjects, 41,7%). The average MMSE score was 20.48 ± 5.000. The average CDT value was 2.90 ± 0.933. There was a significant correlation between the size of the lesion with cognitive aspects of registration, recall, language, visuospatial and executive (p <0.05). There was a significant correlation between location hemisphere lesion with deficite in registration, recall, attention and calculation, visuospatial and executive (p <0.05). Conc/ussion: From this study, we found that the size of lesion effect on registration, recall, language, visuospatial and executive. The location of hemispheric lesion cause more deficit in registration, recall, attention and calculation, visuospatial and executive.