| dc.description.abstract | Background. Atopic dermatitis (AD) is a chronic itchy inflammatory disease
of the skin. The role of synbiotic in treatment of the atopic dermatitis has
shown varying results.
Objective. To determine the effectiveness of synbiotic in AD treatment.
Methods. A randomized controlled triat was conducted from July until August
2015 at primary health centres in Medan. Fifty two children with AD was
included in the study. Subjects were divided into two groups, 26 children in
each group. Group A received synbiotic and emolient, Group B received
placebo (maltodextrin) and emolient. Both groups were followed for 14 days
and SCORAD (Scoring of Atopic Dermatitis) index was assesed to determine
AD severity in day 0, 7, 10, and 14. Data was analysed using Mann Whitney
test.
Results. Mean SCORAD index reduction from day O until 14 of group A was
better than group B, implying that synbiotic has a role in AD treatment. But
unfortunately this result was not statistically significant (P > 0.05). The EER
and CER in this study was 80.77% and 73.08% respectively, NNT score of
synbiotic treatment was 13.00.
Conclusions. Synbiotic was associated with better SCORAD index reduction
in 14 days than placebo, but this was not statistically significant. Synbiotic is
not effective in treatment of AD in children. | en_US |
