| dc.description.abstract | Research on the extraction and immobilization of antibacterial active
compounds in methanol extract of pirdot leaves in semi IPN hydrogel has been carried
out. This study aimed to analyze the antibacterial active compounds from pirdot leaf
extract, evaluate the antibacterial active compounds from the pirdot leaf extract
(Saurauia vulcani, Korth) against the semi IPN hydrogel, as well as analyze the
percentage of crosslinking, water absorption, and antibacterial test of the semi IPN
hydrogel. optimum with the addition of pirdot leaf extract. This research used extraction
method for pirdot leaf extract (Saurauia vulcani, Korth) and crosslinking method to
produce semi IPN hydrogel based on PVA/AA/MBA. Characterization for pridot leaf
extract and IPN hydrogel was carried out using FTIR, GCMS, SEM and antibacterial
tests. The results showed that the methanol extract of pirdot leaves contained secondary
metabolites, namely phenolics, terpenoids, saponins, tannins and steroids (FTIR and
GCMS analysis). The semi IPN hydrogel with the addition of 0.04 g of pirdot leaf extract
had the most optimum swelling percentage and degree of cross-linking, which were
516.28% and 95.12%, respectively. The antibacterial activity test of the semi IPN
hydrogel with the addition of 0.08 g pirdot leaf extract showed the largest inhibition zone
value for Staphylococcus aureus bacteria (19.9 mm ) and the smallest on the semi IPN
hydrogel with the addition of 0.02 g pirdot leaf extract for Escherichia coli bacteria (0
mm ). The results of these studies indicate that the methanol extract of pirdot leaves and
the semi IPN hydrogel based on PVA/AA/MBA immobilized by the methanol extract of
pirdot leaves have antibacterial activity so that they have the potential to be used as
wound and irritation medicine. | en_US |
