Hubungan Imunoglobulin M dan Imunoglobulin G Anti-Toksoplasma, C Reactive Protein, D Dimer dengan Luaran Klinis Toksoplasmosis Serebri pada Penderita HIV Positif di Rumah Sakit Umum Pusat Haji Adam Malik Medan

Abstract

Background Cerebral toxoplasmosis is a neurological emergency in HIV, and therefore requires serious management. Cerebral toxoplasmosis is an indicator of poor prognosis in AIDS patients and contributes to 23% of AIDS patient mortality. Objective This study aimed to examine the relationship between Immunoglobulin M and Immunoglobulin G Anti-Toxoplasma, C-Reactive Protein, and D-dimer with the clinical outcome of cerebral toxoplasmosis in HIV positive patients. Method This study was an observational analytic with a cross-sectional design. The study sample consisted of 20 HIV positive patients treated in the inpatient room (Rindu) RSUP H. Adam Malik Medan who diagnosed cerebral toxoplasmosis based on T. Gondii IgG examination and the radiological examinations. Then the patient was examined for immunoglobulin M, immunoglobulin G, C Reactive Protein, and Ddimer with clinical cerebral toxoplasmosis based on KPS score. Results Majority of subjects were male, as many as 14 people (70%). The mean age of the subjects was 37.3 years. Most of the subjects working as entrepreneurs opened 9 people (45%). The most subject education is senior high school as many as 17 people (85%). A total of 13 subjects (65%) were married. IgM level was not correlated with clinical outcome (p = 0.873). IgG levels was not correlated with clinical outcome (p = 0.594). CRP levels were not correlated with clinical outcome (p = 0.891) and D Dimer levels were not correlated with clinical outcome (p = 0.191). Conclusion There was no significant relationship between Immunoglobulin M, Immunoglobulin G, C-Reactive Protein, and D-dimer (p>0.05).