Perbandingan Efektifitas dan Efek Samping Gabapentin 600 Mg dan Gabapentin 900 Mg per Oral Kombinasi dengan Ketorolac 30 Mg/8 Jam Intravena sebagai Analgesia Paskabedah pada Total Abdominal Histerektomi dengan Anestesi Umum

Abstract

Objective: To assess the efficacy of600 mg oral gabapentin and 900 mg oral gabapentin combined with 30 mg/8 houts intravenous ketorolac as postoperative alalgesics for total abdominal hysterectomy under general anesthesia towards Yisual analogue scale (VAS) and side effects in 24 hours postoperatively. Method: Double blind controlled trial was performedto 30 research subjects, at the age of l8-60 years old with PS-ASA 1-2 that would undergo total aMominal hyster€€tomy with general anesthesia. All of the subjecs were divided into 3 groups. Group A got placebo, group B got 600 mg oral gabapentin and group C got 900 mg oral gabapentin combined with intravenous 30 mgl8 hours ketorolac. The efficacy was ass€ssed with post operative visual analogue scale (VAS), side effect incidence, and the need of rescue analgesia pethidin in 24 hours postoperatively. Result: When being compared, the VAS score of the group that took 600 mg oral gabapentin and t}re group that took 900 mg oral gabap€ntin combined with 30 mglhours intravenous ketorolac showed no significant difference (P0,05), but there was a significant difference of postoperative VAS score between placebo group with the group that took 600 mg oral gabapentin and with the grouP that took 900 mg oral gabapentin combined with 30 mgiS hours intravenous ketomlac at the second hour monitoring (p<0,001) and the fourth hour monitoring (IF0,045). At the later rnonitoring there was no significant VAS score difference among these three groups (P0,05). The side effect incidence and the need of rescue analgesia pethidin in 24 hours postop€ratively showed no signifrcant difference ,rmong the three groups (P0,05) Conclu$ion: The effects of 600 mg oral gabapentin and the effects of 9fl) mg oral gabapentin combined with 30 mg/8 hours intravenous ketorolac as postoperative analgesics for total abdominal hysterectomy under general anesthesia were not different in decrrasing VAS score, side ellect inoi&ncent and the need of rescue analgesia pethidine in 24 hours postoperatively