| dc.description.abstract | Background Fungal infection may cause late-onset sepsis in low birth
weight infants. lnvasive fungal infection (lFl) is a cause of morbidity and
mortality in neonates. A number of potential factors for the development of
lFl have been identified including low birth weight, gestational age <32
weeks, vaginal delivery, use of broad spectrum antibiotics such as third-
generation cephalosporin and carbamapenem, cenfal venous catheters,
mechanical ventilation, parenteral nutrition, intralipid, abdominal surgery,
necrotizing enterocolitis, prolonged hospitalized, and thrombocytopenia.
Objective To determine risk factors of invasive fungal infection in low birth
weight exposure to third-generation cephalosporin
Methods A cross sectional study has been done on October 2011 to April
2012 with participants 82 low birth weight infant < 2500 g with suspected
sepsis and exposure to antibiotics third-generation cephalosporin :5
days. lFl was diagnosed on positive fungal culture from blood. Statistical
analyses used was Fisher exact test and multivariate logistic regression to
assess risk factor$ of lFl
Results Of 82 low birth weight infunts included subjects, 9 infants (10,9%)
were proved to have lFl. Candida albicans was the most fungal species
causing lFl. There was a significant association between parenteral
nutrition and intralipid with lFl (P < 0.05). Lipid use was risk factor lFl (OR
= 9.95; Cl 957o = 1.90 - 52.16, P=0.007) by multivariate analysis
Conclusions The use of lipid retained significance as an independent risk
factor of invasive fungal infection. | en_US |
