| dc.description.abstract | The Histologic Description of Male Mice (Mus musculus L.) Kidney Treated
With Fresh Andaliman (Zanthoxylum acanthopodium DC.) Fruit Extract has
been studied from March 2013 to November 2014. The study used completely
randomized design (CRD) consisting of 4 treatment groups; control (K0), and
treatment with 2% (P1), 5% (P2), and 10% (P3) of fresh andaliman fruit extract
for 40 days and continued for 40 days without treatment to examine recovery.
Each treatment group consisted of 6 mice. Mice were dissected after 40 and 80
days of treatment, the kidneys were obtained, weighed, and made into
microscopic slides for histologic examination using paraffin method and
Hematoxyline Eosin (HE) stain. Morphological examination showed color change
in P2 treatment group. No significant difference was observed in kidneys weight
between treatment and control group. Histologic examination of glomeruli
diameter and proximal tubuli diameter showed an increase in diameter of
glomeruli in all treatment groups (P1, P2, and P3) but a decrease in diameter of
proximal tubuli in P1 treatment group compared to control group. Recovery phase
showed a decrease in proximal tubuli diameter compared to pre-recovery phase. | en_US |
