| dc.description.abstract | Testosterone Undecanoate (TU) is one of steroid compound which was developed for
male contraception in the form of injections (liquid). Seed of blustru plant (Luffa
aegyptica Roxb.) contains alkaloid that is cytotoxic and has antifertility effect. The
purpose of this research is to observe influence of combination of TU and water
extract of blustru seed to histological picture, weight and volume of mice testes from
week 0 until week 24. The research has been done from July 2009 until September
2010 with complete random design (RAL) that consists of five (5) treatments (P0, P1,
P2, P3 and P4) and controls (K0, K1, K2, K3, K4) where each of them have 5
replications. The time interval intramuscular injection of TU (0.25 mg / mice) was 6
weeks and water extract of blustru seed (270mg / mice) was given orally daily that
starting from week 0 until week 24. The results of research showed that combination
of Testosterone Undecanoate (TU) and water extract of blustru (Luffa aegyptica
Roxb.) seed had effect to histological picture at the treatment of 12 weeks and 18
weeks that happened declining of spermatogenic cells and treatment of 24 weeks
happened recovery on spermatogenic cells. The result of testes weight of mice at the
treatment of 12 weeks and 18 weeks were declined of testes weight significantly
(p<0,05) and treatmentof 24 weeks happened recovery on weight of mice testes. The
combination of TU and water extract of blustru seed had no significant effect
(p>0,05) on the volume and diameter of seminiferous tubulus of mice testes. | en_US |
