Gambaran Histologis Testis Mencit (Mus Musculus L.) yang Mendapat Kombinasi Ekstrak Air Biji Pepaya (Carica Papaya L.) dan Testosteron Undekanoat (Tu)

Abstract

Many traditional use of medicinal plants to treat different sort of disease, including fertility has done. This research observed the influence of papaya seed (Carica papaya L.) extract and Testosterone Undekanoat (TU) combination in testicle histology of mice (Mus musculus L.) which designed in complete random design (RAL) that divide to 5 control groups and 5 treatment groups. The papaya seed extract (30mg/day) gived orally from 0 week until 24 weeks. The time interval for intramuscular injection was by 6 weeks. This research resulted the suppression of testiscle weight significantly (p<0,05) in 24 weeks and volume reduction in 18 for 24 weeks significantly during research . The combination of seed extract of papaya (Carica papaya L.) and hormonal contraception, Testosterone Undekanoat (TU) in mice caused reduction of diameter and germinal layer wide significantly in 24 weeks.