Gambaran Histologis Hepar Mencit (Mus Musculus L.) Strain Ddw setelah Pemberian Ekstrak N-Heksan Buah Andaliman (Zanthoxylum Acanthopodium Dc.) Selama Masa Pra Implantasi dan Pasca Implantasi

Abstract

The Histologic Description of Mice Liver (Mus musculus L.) Strain DDW Treated of N-Heksane Andaliman Fruit (Zanthoxylum acanthopodium DC.) Extract During Pre Implantation and Post Implantation has been studied from March 2011 to May 2012 in Laboratory of Animal Structure, Department of Biology, Faculty of Mathematics and Natural Science, University of Sumatera Utara, Medan. This research used completely randomized design (CRD) consist of 2 groups of treatment, the treatment of pre-implantation during 0-3 days (group A) and the treatment of postimplantation during 6-14 days (group B). Each group consisted of giving control treatment (K0A and K0B), solvent control treatment carboxyl methyl cellulose (CMC) 1% (KPA and KPB), n-hexane andaliman fruit extract 2% (PA1 and PB1), 4% (PA2 and PB2 ), and 6% (PA3 and PB3). Each treatment consisted of 6 replications. Mice were treated orally using a gavage needle as much as 0.3ml/mice/day. The result of morphologic observation on liver showed a pale and mottled surface texture in treatment groups. The giving of post-implantation 6-14 days showed decrease of liver weight (p> 0.05) than in treatment group in the giving of pre implantation 0-3 days. The giving of post-implantation 6-14 days showed increase of hepatocyte damage (p> 0.05) than in treatment group in the giving of pre implantation 0-3 days. From the result of this analysis, it could be then concluded that the n-hexane andaliman fruit extract is negatively impact on histological of liver mice.