| dc.description.abstract | The Histologic Description of Mice Liver (Mus musculus L.) Strain DDW Treated
of N-Heksane Andaliman Fruit (Zanthoxylum acanthopodium DC.) Extract During
Pre Implantation and Post Implantation has been studied from March 2011 to May
2012 in Laboratory of Animal Structure, Department of Biology, Faculty of
Mathematics and Natural Science, University of Sumatera Utara, Medan. This
research used completely randomized design (CRD) consist of 2 groups of treatment,
the treatment of pre-implantation during 0-3 days (group A) and the treatment of postimplantation
during 6-14 days (group B). Each group consisted of giving control
treatment (K0A and K0B), solvent control treatment carboxyl methyl cellulose (CMC)
1% (KPA and KPB), n-hexane andaliman fruit extract 2% (PA1 and PB1), 4% (PA2
and PB2 ), and 6% (PA3 and PB3). Each treatment consisted of 6 replications. Mice
were treated orally using a gavage needle as much as 0.3ml/mice/day. The result of
morphologic observation on liver showed a pale and mottled surface texture in
treatment groups. The giving of post-implantation 6-14 days showed decrease of liver
weight (p> 0.05) than in treatment group in the giving of pre implantation 0-3 days.
The giving of post-implantation 6-14 days showed increase of hepatocyte damage (p>
0.05) than in treatment group in the giving of pre implantation 0-3 days. From the
result of this analysis, it could be then concluded that the n-hexane andaliman fruit
extract is negatively impact on histological of liver mice. | en_US |
