| dc.description.abstract | This study aimed to determine the effect of vitamin C and E on testicular histology of
mouse following exposure to monosodium glutamate (MSG) for 30 days.
Experimental used Completely Randomized Design (CRD) consisting of 6 treatments
and 5 replications. Mice were treated daily by oral gavage with 4 mg MSG (P1), 4 mg
MSG + 0.26 mg vitamin C (P2), 4 mg MSG + 0.026 vitamin E (P3), and 4 mg
MSG + 0.26 mg vitamin C + 0.026 mg vitamin E (P4). All dosis were in mg/g body
weight. Two control groups K- and K+ received water and castrol oil respectively.
The results showed that MSG decrease testis weight and testis volume (P<0,05), also
decrease diameter of seminiferous tubule and the number of spermatogenic cells.
Vitamin C recover testis weight (P<0,05), but cannot recover testis volume, diameter
of seminiferous tubules and the number spermatogenic cells (P>0,05). Vitamin E
increase the weight and volume of the testes and spermatogenic cell number (P<0,05),
but unable to recover the diameter of the seminiferous tubules (P>0,05). Combination
of vitamin C and E recover testicular weight and volume,
seminiferous tubule diameter and the number of spermatogenic cells (P<0,05). | en_US |
